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Biotechnology Research in an Age of Terrorism (2004)

Chapter: Appendix B: Biographical Sketches of Committee Members

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Suggested Citation:"Appendix B: Biographical Sketches of Committee Members." National Research Council. 2004. Biotechnology Research in an Age of Terrorism. Washington, DC: The National Academies Press. doi: 10.17226/10827.
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Suggested Citation:"Appendix B: Biographical Sketches of Committee Members." National Research Council. 2004. Biotechnology Research in an Age of Terrorism. Washington, DC: The National Academies Press. doi: 10.17226/10827.
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Suggested Citation:"Appendix B: Biographical Sketches of Committee Members." National Research Council. 2004. Biotechnology Research in an Age of Terrorism. Washington, DC: The National Academies Press. doi: 10.17226/10827.
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Suggested Citation:"Appendix B: Biographical Sketches of Committee Members." National Research Council. 2004. Biotechnology Research in an Age of Terrorism. Washington, DC: The National Academies Press. doi: 10.17226/10827.
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Suggested Citation:"Appendix B: Biographical Sketches of Committee Members." National Research Council. 2004. Biotechnology Research in an Age of Terrorism. Washington, DC: The National Academies Press. doi: 10.17226/10827.
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Suggested Citation:"Appendix B: Biographical Sketches of Committee Members." National Research Council. 2004. Biotechnology Research in an Age of Terrorism. Washington, DC: The National Academies Press. doi: 10.17226/10827.
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Suggested Citation:"Appendix B: Biographical Sketches of Committee Members." National Research Council. 2004. Biotechnology Research in an Age of Terrorism. Washington, DC: The National Academies Press. doi: 10.17226/10827.
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Suggested Citation:"Appendix B: Biographical Sketches of Committee Members." National Research Council. 2004. Biotechnology Research in an Age of Terrorism. Washington, DC: The National Academies Press. doi: 10.17226/10827.
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Appendix B Biographical Sketches of Committee Members Gerald R. Fink (NAS, IOM) is a professor of genetics, Whitehead Insti- tute, Massachusetts Institute of Technology. Dr. Fink is a founding mem- ber of the Whitehead Institute and American Cancer Society Professor of Genetics at MIT, Dr. Fink was Director of the Whitehead Institute from 1990 to 2001. He received his B.A. from Amherst College in 1962 and his Ph.D. from Yale in 1965. In addition, he has received honorary doctorates from Amherst College and Cold Spring Harbor Laboratory. His research focuses on the molecular biology of fungal infectious disease. He served as president of the Genetics Society of America. Among his many awards are the National Academy of Sciences Award in Molecular Biology, the Medal of the Genetics Society of America, Emil Christian Hansen Award (Denmark), the Yale Science and Engineering Award, and the 2001 George Beadle Award. He has been elected to the National Academy of Sciences, the American Academy of Arts and Sciences, the Institute of Medicine and the American Philosophical Society. He is currently a Senior Scholar in Infectious Disease of the Ellison Foundation. Ronald Atlas is a professor of biology and graduate dean at the Univer- sity of Louisville. He is the Director of the Center for Deterrence of Biowarfare and Bioterrorism. Dr. Atlas' studies have focused on the ap- plication of molecular techniques to environmental problems. His studies have included the development of "suicide vectors" for the containment of genetically engineered microorganisms and the use of gene probes and the polymerase chain reaction for environmental monitoring. He received a BS degree from the State University of New York at Stony Brook in 1968, 135

136 APPENDIX B an M.S. from Rutgers University in 1970 and a Ph.D. from Rutgers Uni- versity in 1972. He then served for a year as a National Research Council Research Associate at the let Propulsion Laboratory. He is the immediate past-president of the American Society for Microbiology and was the re- cipient of the American Society for Microbiology award in Applied and Environmental Sciences. W. Emmett Barkley is Director of Laboratory Safety at the Howard Hughes Medical Institute (HHMI). Dr. Barkley directed the National Can- cer Institute's Office of Research Safety and the divisions of safety and engineering services at the National Institutes of Health prior to joining HHMI. He received his B.S. in civil engineering from the University of Virginia and his M.S. and Ph.D. in environmental health from the Univer- sity of Minnesota. Dr. Barkley has received several awards including the Distinguished Service Medal of the U.S. Public Health Service. He has previously served the Academies on several committees including the NRC Committee on Prudent Practices for Handling, Storage, and Disposal of Chemicals in the Laboratory and served as the chair of the Committee on Safety and Health in Research Animal Facilities. R. lohn Collier (NAS) is Presley Professor of Microbiology and Molecular Genetics in the Department of Microbiology and Molecular Genetics at Harvard Medical School. His scientific contributions include: demonstrat- ing that Diphtheria toxin blocks protein synthesis by inactivating Elonga- tion Factor-2; elucidating Diphtheria toxin structure, as containing enzy- matic (A) and binding (B) fragments; identifying GLU-148 as a key active-site residue; developing A-chain immunotoxin concepts; crystalliz- ing Diphtheria and Pseudomonas toxins and determining Pseudomonas toxin's structure. His studies in recent years have focused on the structure and mode of action of anthrax toxin, and ways to inhibit its action. Susan E. Cozzens is Professor and Chair of the School of Public Policy at the Georgia Institute of Technology. Her current research is on sci- ence, technology, and inequalities. She is active internationally in devel- oping research assessment methods and science and technology indica- tors. Dr. Cozzens had previously been Director of the Office of Policy Support at the National Science Foundation and has served as a consult- ant to several organizations including the Committee on Science, Engi- neering and Public Policy of the National Research Council, Office of Science and Technology Policy, National Science Foundation, Institute of Medicine, Office of Technology Assessment, General Accounting Of- fice, National Cancer Institute, National Institute on Aging, National Institutes of Health, and the National Institute on Occupational Safety

APPENDIX B 137 and Health. She has given speeches on science policy and research evalu- ation all around the world and has many publications on science policy and science and technology studies. Ruth Faden (IOM) is Philip Franklin Wagley Professor of Biomedical Eth- ics and Executive Director of the Phoebe R. Berman Bioethics Institute, Johns Hopkins University. Dr. Faden is also a Senior Research Scholar at the Kennedy Institute of Ethics, Georgetown University. She is a Fellow of the Hastings Center and the American Psychological Association and has served on several national advisory committees and commissions. David R. Franz is currently Vice President of Chemical & Biological De- fense Division at Southern Research Institute. He has served in the U.S. Army Medical Research and Materiel Command for 23 of his 27 years on active duty. Dr. Franz has served as both Deputy Commander and then Commander of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) and as Deputy Commander of the U.S. Army Medi- cal Research and Materiel Command. Prior to joining the Command, he served as Group Veterinarian for the 10th Special Forces Group (Air- borne). Dr. Franz served as Chief Inspector on three United Nations Spe- cial Commission biological warfare inspection missions to Iraq, and as technical advisor on long-term monitoring. He also served as a member of the first two US/UK teams that visited Russia in support of the Trilat- eral Joint Statement on Biological Weapons, and as a member of the Tri- lateral Experts Committee for biological weapons negotiations. While at the Medical Research and Materiel Command, he was assigned to four of its laboratories, personally conducting research and publishing in the ar- eas of frostbite pathogenesis, organophosphate chemical warfare agent effects on pulmonary and upper airways function, the role of cell-medi- ated small vessel dysfunction in cerebral malaria, and the development of medical countermeasures against biological agents. Dr. Franz was Tech- nical Editor for the Textbook of Military Medicine on Chemical and Bio- logical Defense released in 1997. Joseph L. Goldstein (NAS, IOM) is Regental Professor and Chairman of the Department of Molecular Genetics and Paul I. Thomas Professor of Medicine and Genetics at the University of Texas Southwestern Medical Center at Dallas. Together with his colleague Dr. Michael S. Brown, Dr. Goldstein has received numerous awards including the Albert D. Lasker Award in Basic Medical Research, the Nobel Prize in Physiology or Medi- cine, and the National Medal of Science for their discovery of receptors that control cholesterol metabolism, Dr. Goldstein's area of expertise is hu- man genetics and cholesterol metabolism. He is a member of the U.S. Na-

138 APPENDIX B tional Academy of Sciences, American Philosophical Society, and the Insti- tute of Medicine. He is also a Foreign Member of The Royal Society (Lon- don). He is a past president of the American Society for Clinical Investiga- tion and was a member of the Governing Council of the U.S. National Academy of Sciences. He has also served on the Scientific Review Board and Medical Advisory Board of the Howard Hughes Medical Institute and on the NIH Program Advisory Committee on the Human Genome. He was a Non-Resident Fellow of The Salk Institute. Dr. Goldstein is currently Chairman of the Medical Advisory Board of the Howard Hughes Medical Institute, Chairman of the Albert Lasker Medical Research Awards fury, and a member of the Board of Trustees of The Rockefeller University. He is a member of the Scientific Advisory Boards of the Welch Foundation, Me- morial-Sloan Kettering Medical Center, and the Scripps Research Institute. Robert Kadlec is a Professor of Military Strategy and Operations at Na- tional Defense University. He is an Air Force physician who joined the National War College Faculty in December 1999. Cot. Kadlec served as a Senior Assistant for Counter proliferation Policy in the Office of the Secre- tary of Defense (OSD) for Policy, was a member of the Joint Chiefs of Staff, and represented OSD on the U.S. delegation to the Biological Weap- ons Convention in Geneva, Switzerland. He is board certified in both Gen- eral Preventive Medicine & Public Health and Aerospace Medicine and is an Assistant Clinical Professor of Military Medicine at USUHS. Cot. Kadlec also served as an UNSCOM inspector in Iraq. Barry Kellman is the Director of the International Weapons Control Cen- ter at the DePaul University College of Law. He served as legal adviser to the National Commission on Terrorism in 2000, and is currently a con- sultant for the Memorial Institute for the Prevention of Terrorism, prepar- ing a series of monographs on Legal Authorities and Liabilities for Cata- strophic Terrorism. He chairs the ABA Committee on Law and National Security as well as the Arms Control Section of the American Society of International Law. In addition to his work on terrorism, Professor Kellman is a legal authority on the Chemical Weapons Convention and has served as a consultant to the Defense Department on a wide array of weapons control issues. Since 1995, he has participated in Track-2 discussions of Middle East arms control. He has published widely on weapons prolif- eration and smuggling, national security, and the laws of armed conflict; and he has written the only legal publications on biological terrorism: Biological Terrorism: Legal Measures for Preventing Catastrophe, Spring 2001; and An International Criminal Law Approach To Bio-Terrorism, Spring 2002.

APPENDIX B 139 Marc Kirschner (NAS) is Chair and Carl W. Walter Professor of Cell Biol- ogy, Department of Cell Biology, Harvard Medical School. His main areas of study are cell biology, cytoskeleton, cell cycle, and vertebrate embryol- ogy. Dr. Kirschner is well known for discoveries on microtubule assembly and the analysis of tubulin genes and for the contributions to molecular analysis of amphibian development, especially the control of the early cell cycles during embryogenesis and molecular event in embryonic induc- tion. Dr. Kirschner was elected Foreign member of the Royal Society of London in 1999. He is a member of the American Academy of Arts and Sciences and has served on the Advisory Committee to the Director of the National Institutes of Health and as President of the American Society for Cell Biology. Erin O'Shea is a Professor and Vice Chair of the Department of Biochem- istry & Biophysics at the University of California at San Francisco and an Assistant Investigator of the Howard Hughes Medical Institute. Her re- search interests include signal transduction and gene regulation and the use of genomic and proteomic approaches to study eukaryotic cells. Her awards include a David and Lucite Packard Fellowship, a Presidential Faculty Fellow Award, the American Society for Cell Biology-Promega Early Career Life Scientist Award, and the National Academy of Sciences Award in Molecular Biology. She has served in several advisory roles, including: Scientific Advisory Board, Helen Hay Whitney Foundation; Chairman, Scientific Advisory Board, Boston University School of Medi- cine Department of Genetics and Genomics; External Review Committee, Lawrence Berkeley National Laboratory Division of Physical Biosciences. She has previously served the Academies on the HHMI Predoctoral Fel- lowships Panel on Biochemistry and Structural Biology. Clarence l. Peters is currently a professor in the Department of Microbi- ology & Immunology and Pathology at the University of Texas Medical Branch in Galveston. He had been Chief of Special Pathogens at the Cen- ters for Disease Control in Atlanta, Georgia. Formerly Chief of the Dis- ease Assessment Division at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), he has worked in the field of infec- tious diseases for three decades with the CDC, the U.S. Army, and the U.S. Public Health Service. He was the head of the unit that contained the outbreak of Ebola in Rhesus macaques at a Reston, Virginia animal facility. He was also called in to contain an outbreak of deadly hemor- rhagic fever in Bolivia. He received his M.D. from Johns Hopkins Uni- versity and has more than 275 publications in the areas of virology and viral immunology. Dr. Peters is currently a member of the National Re- search Council Committee on Occupational Health and Safety in Care of

140 APPENDIX B Nonhuman Primates and the Committee on Emerging Microbial Threats to Health in the 21st Century. Judith V. Reppy is a professor in the Department of Science and Technol- ogy Studies and associate director of the Peace Studies Program of Cornell University. She is an adjunct member of the Department of Government. She has been a visiting fellow at Science & Technology Studies (Manches- ter University), the Science Policy Research Unit (Sussex University), and the Center for International Studies (MIT). She is a member of the Council on Foreign Relations, the Boards of Directors of The Federation of Ameri- can Scientists, Economists Allied for Arms Reduction (ECAAR) and the Institute for Defense and Disarmament Studies (IDDS), and the Advisory Board of Women in International Security (WIIS). She served as co-chair of US Pugwash from 1995-2000. Dr. Reppy is the author, co-author, and contributing editor of several books, as well as numerous articles and con- tributed chapters in edited works. Elizabeth Rindskopf Parker is Dean of the University of the Pacific McGeorge School of Law. Ms. Rindskopf Parker is a leading expert on anti-terrorism law. Her expertise includes law of national security and terrorism; international relations; public policy and technology develop- ment; and transfer, commerce, and litigation in the area of civil rights and liberties. Ms. Rindskopf Parker was General Counsel to the University of Wisconsin System and Counsel to the international law firm of Bryan Cave, LLP where her practice focused on counseling clients on public policy and international trade issues. She previously served as the Gen- eral Counsel for the Central Intelligence Agency; Principal Deputy Legal Adviser for the U.S. Department of State; General Counsel for the Na- tional Security Agency, Department of Defense; and Acting Assistant Di- rector for the Federal Trade Commission. Ms. Rindskopf Parker often speaks on subjects dealing with the law of national security. She is a mem- ber of the Council on Foreign Relations, past chair of the ABA Standing Committee on Law and National Security and currently a member of the ABA President's Task Force on the Laws of Terrorism. Matthew Scharff (NAS) is Professor of Cell Biology, Albert Einstein School of Medicine. Dr. Scharff has served in several advisory roles in- cluding, Outside Advisory Committees for NIEHS Center of Environmen- tal Medicine at N.Y.U. Cancer Center at N.Y.U. and the Cancer Center, University of Pennsylvania, Scientific Advisory Board, Helen Hay Whitney Foundation; chairman, Scientific Advisory Board, Rappaport Family Institute, Haifa, Israel; Scientific Advisory Board, City of Hope; Scientific Advisory Board, Simons Arthritis Center, University of Texas,

APPENDIX B 141 Southwestern Medical School, Dallas; Co-Chairman, Board of Scientific Counselors, Division of Basic Sciences, NCI; member of NCI Executive Committee; Advisory Committee to the Director of the NCI. His current research is being used to create better monoclonal antibodies for the treat- ment and prevention of disease. Morton Schwartz is Chairman of the Department of Clinical Laboratories and Head of Applied and Diagnostic Biochemistry at the Memorial Sloan Kettering Cancer Center. After serving with the U.S. Navy during World War II, he was a U.S. Public Health Service Fellow from 1950-1952. Dr. Schwartz is a member of several professional associations, including the American Association of Clinical Chemistry, which gave him its Service to the Profession Award in 1988. His expertise is Clinical Chemistry. Edward Scolnick (NAS, IOM) is President Emeritus, Merck Research Laboratories and Executive Vice President for Science and Technology with Merck & Company, Inc. Dr. Scolnick was elected to the National Academy of Sciences in 1984 and to the American Academy of Arts and Sciences in 1993. He became a member of the Institute of Medicine in 1996 and in 1997 was elected to the Merck & Co., Inc. Board of Directors. He currently serves on the Board of Directors for Millipore Corporation, Renovis, Inc., Cold Spring Harbor Laboratory, Harvard Medical School, Protein Pathways, GeneSoft, Inc., TransForm Pharmaceuticals, Inc., the Medical and Scientific Advisory Board for MPM Capital, and was recently appointed to the Governor's Pennsylvania Health Research Advisory Committee. In addition, he is a Member of the FDA Science Board. Dr. Scolnick's commitment to the mental health field is evidenced by mem- berships on the Board of Directors for McLean Hospital, McGovern Insti- tute for Brain Research, Pennsylvania Montgomery County Emergency Services, and as President of the Pennsylvania Montgomery County Chap- ter of the National Alliance for the Mentally Ill. He is also a board member of the National Institute of Mental Health Council.

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In recent years much has happened to justify an examination of biological research in light of national security concerns. The destructive application of biotechnology research includes activities such as spreading common pathogens or transforming them into even more lethal forms. Policymakers and the scientific community at large must put forth a vigorous and immediate response to this challenge. This new book by the National Research Council recommends that the government expand existing regulations and rely on self-governance by scientists rather than adopt intrusive new policies. One key recommendation of the report is that the government should not attempt to regulate scientific publishing but should trust scientists and journals to screen their papers for security risks, a task some journals have already taken up. With biological information and tools widely distributed, regulating only U.S. researchers would have little effect. A new International Forum on Biosecurity should encourage the adoption of similar measures around the world. Seven types of risky studies would require approval by the Institutional Biosafety Committees that already oversee recombinant DNA research at some 400 U.S. institutions. These "experiments of concern" include making an infectious agent more lethal and rendering vaccines powerless.

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